Galectin-3, N-terminal Propeptides of Type I and III Procollagen in Patients with Atrial Fibrillation and Metabolic Syndrome
| Autor: | Ekaterina L Zaslavskaya, Elena Yu Petrishcheva, E. Shlyakhto, Elena Baranova, Aleksandr N Morozov, V. Ionin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Galectin 3 Left atrium 030204 cardiovascular system & hematology Gastroenterology lcsh:Chemistry 0302 clinical medicine Fibrosis Risk Factors atrial fibrillation lcsh:QH301-705.5 Spectroscopy PIIINP Atrial fibrillation General Medicine Middle Aged Computer Science Applications medicine.anatomical_structure Galectin-3 Female Procollagen Adult medicine.medical_specialty Catalysis Article metabolic syndrome Inorganic Chemistry 03 medical and health sciences Internal medicine galectin-3 medicine Humans In patient Physical and Theoretical Chemistry Protein precursor Molecular Biology business.industry Organic Chemistry fibrosis medicine.disease Peptide Fragments Procollagen peptidase 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 ROC Curve PINP Metabolic syndrome business Biomarkers |
| Zdroj: | International Journal of Molecular Sciences Volume 21 Issue 16 International Journal of Molecular Sciences, Vol 21, Iss 5689, p 5689 (2020) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms21165689 |
| Popis: | The aim of this study was to determine the concentration of galectin-3, PINP and PIIINP in patients with metabolic syndrome (MS) and atrial fibrillation (AF) with an assessment of the relationship with severity of left atrium fibrosis. A total of 480 subjects were included in the case-control study: MS patients (n = 337), 176 of whom had AF, 72 patients with AF without MS and 71 healthy subjects. Galectin-3, PINP and PIIINP blood concentrations and metabolic parameters were compared with the severity of left atrium fibrosis, measured by CARTO3. Galectin-3 in AF and MS patients is higher than in MS without AF and in healthy subjects (10.3 (4.8&ndash 15.4), 5.1 (4.3&ndash 8.8), 3.2 (2.4&ndash 4.2) ng/mL, p < 0.0001). Galectin-3 serum concentration in AF patients with MS is higher than in patients without MS: 10.3 (4.8&ndash 15.4), 6.8 (5.2&ndash 8.1) ng/mL, p = 0.0001. PINP and PIIINP concentration were higher in patients with AF and MS than in MS without AF: 3499.1 (2299.2&ndash 4567.3), 2130.9 (1425.3&ndash 2861.8) pg/mL, p < 0.0001, 94.9 (64.8&ndash 123.5), 57.6 (40.5&ndash 86.9) ng/mL, p < 0.0001. Galectin-3 correlates with PINP (r = 0.496, p < 0.001) and PIIINP concentration (r = 0.451, p < 0.0001). The correlation between galectin-3, PINP and the severity of left atrium fibrosis was found (r = 0.410, p < 0.001 r = 0.623, p < 0.001). Galectin-3 higher than 12.6 ng/mL increased the risk of AF more than five-fold. High galectin-3, PINP and PIIINP concentrations were associated with heart remodeling in MS patients and increased the risk of AF. |
| Databáze: | OpenAIRE |
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