Non-alcoholic fatty liver disease in an area of southern Italy: main clinical, histological, and pathophysiological aspects
| Autor: | Vincenzo De Girolamo, Camillo Del Vecchio Blanco, Veronica Verde, Luigi Terracciano, Maria Marino, Concetta Tuccillo, Raffaella Vecchione, Filomena Morisco, Antonio Ascione, F.P. Picciotto, Carmela Loguercio, L. Cimino, Gabriele Budillon, Feliciano Baldi, Antonio Di Carlo, Ilario de Sio |
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| Přispěvatelé: | Loguercio, Carmelina, DE GIROLAMO, V, DE SIO, I, Tuccillo, C, Ascione, A, Baldi, F, Budillon, G, Cimino, L, DI CARLO, A, DI MARINO, Mp, Morisco, F, Picciotto, F, Terracciano, L, Vecchione, R, Verde, V, DEL VECCHIO BLANCO, C., Loguercio, C, Budillon, Gabriele, Morisco, Filomena |
| Rok vydání: | 2001 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Cirrhosis Adolescent Alcohol Drinking Iron Chronic liver disease Gastroenterology Body Mass Index Diabetes mellitus genetics Malondialdehyde Internal medicine Insulin Secretion Diabetes Mellitus medicine Hyperinsulinemia Humans Insulin Aspartate Aminotransferases Triglycerides Aged Sex Characteristics Hepatology medicine.diagnostic_test business.industry Liver Diseases Fatty liver nutritional and metabolic diseases Alanine Transaminase Middle Aged Alkaline Phosphatase medicine.disease Fatty Liver Cholesterol Endocrinology Italy Liver biopsy Female Steatohepatitis Energy Intake business Dyslipidemia |
| Zdroj: | Journal of Hepatology. 35:568-574 |
| ISSN: | 0168-8278 |
| Popis: | Background/Aims : Studies on non-alcoholic fatty liver disease (NAFLD) have included chronic liver damage attributed to various causes. Our investigation was held to observe the main clinical, histological, and pathophysiological aspects of NAFLD in patients not exposed to any known cause of chronic liver disease. Methods : We evaluated, in 84 in-patients (male/female, 66/18; median age, 36 years), the clinical and biochemical characteristics of NAFLD, and particularly its association with diabetes, dyslipidemia, hyperinsulinemia and/or with the increase of parameters of oxidative stress (blood levels of malonyldialdehyde, 4-hydroxynonenal and total plasma antioxidant capacity). Results : Ninety percent of patients had an increased body mass index (BMI), 35% had dyslipidemia, 40% had sub-clinical diabetes (only 3% had overt diabetes), 60% had hyperinsulinemia, and more than 90% had enhanced levels of lipid peroxidation markers. In 48 patients who had consented to liver biopsy, we found: 14 with simple steatosis, 32 with steatohepatitis, and two with cirrhosis. Conclusions : Our data indicate that in our country, NAFLD may occur in young males with an increased BMI, with or without hyperinsulinemia, dyslipidemia and diabetes, generally associated with disorders of redox status, and that it may be differentiated from steatosis to steatohepatitis or cirrhosis only with a liver biopsy. |
| Databáze: | OpenAIRE |
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