Oxfendazole treatment of non-parasitized lambs and its effect on the immune system
| Autor: | L.G. Moore, W.E. Jonas, Chie Wn, M. Stankiewicz, W. Cabaj |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Cellular immunity Oxfendazole Lymphocyte Activation Nitric Oxide Complement Hemolytic Activity Assay Immunoenzyme Techniques Antigen Internal medicine medicine Animals Antigens Insulin-Like Growth Factor I Phytohaemagglutinin Sheep General Veterinary biology Body Weight Hemagglutination Tests General Medicine Ovalbumin Endocrinology Concanavalin A Growth Hormone Immune System Antibody Formation Humoral immunity biology.protein Benzimidazoles Antibody |
| Zdroj: | Veterinary Research Communications. 18:7-18 |
| ISSN: | 1573-7446 0165-7380 |
| DOI: | 10.1007/bf01839256 |
| Popis: | Ten parasite-free lambs were drenched with oxfendazole on days 0 and 28 and, one day after each drench, were injected with human erythrocytes and ovalbumin. Ten other antigen-injected lambs were not drenched (controls). Lymphocytes collected 3 days after each antigen injection and cultured in RPMI 1640 plus 5% fetal calf serum (FCS) and lymphocytes collected 3 days after the first and 3 and 7 days after the second antigen injection and cultured in 50% autologous serum had decreased blastogenic activity compared with control lymphocytes. After the second drench, decreased blastogenesis was seen with lymphocytes collected on days 3 and 7 and cultured in 5% FCS and concanavalin A (Con A) and on day 3 when cultured in 5% FCS and phytohaemagglutinin (PHA). Decreased blastogenesis was also seen with lymphocytes collected 7 and 29 days after the second injection of antigen and cultured in 50% autologous serum plus Con A and on days 3, 7 and 29 when cultured in 50% autologous serum and PHA. Significantly depressed antibody responses to both antigens were seen after the second drench. The serum complement level was depressed 3 days after the second injection of antigen. Serum nitric oxide levels were significantly depressed 3 and 21 days after the first and 7 and 21 days after the second injection of antigen. There were no differences in levels of growth-promoting hormones but the drenched lambs gained significantly more weight than the controls. |
| Databáze: | OpenAIRE |
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