Giants and monsters: Unexpected characters in the story of cancer recurrence
| Autor: | Christina Voelkel-Johnson, Shai White-Gilbertson |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cell type
Epithelial-Mesenchymal Transition Cell cycle checkpoint Population Biology Cancer recurrence Article Polyploidy 03 medical and health sciences 0302 clinical medicine Neoplasms Tumor Microenvironment medicine Animals Humans education Tumor microenvironment education.field_of_study Mechanism (biology) Cancer Cell Cycle Checkpoints medicine.disease 030220 oncology & carcinogenesis Cancer cell Neoplastic Stem Cells Cancer research Neoplasm Recurrence Local |
| Zdroj: | Adv Cancer Res |
| DOI: | 10.1016/bs.acr.2020.03.001 |
| Popis: | Polyploid giant cancer cells (PGCC) constitute a dangerous subpopulation of cancer cells and are a driving force in cancer recurrence. These unique cells arise from diploid tumor cells in response to stress encountered in the tumor microenvironment or during cancer therapy. PGCC are greatly dedifferentiated, acquire pluripotency, and are able to replicate through a form of asymmetric division called neosis, which results in new populations that are themselves able to differentiate into new cell types or to re-establish tumors. Progeny tend to be more genetically unstable than the founding population due to the dysregulation required to transition through a PGCC state. Therefore, cancers that escape stressors through this mechanism tend to re-emerge with a more aggressive phenotype that is therapy resistant. This review focuses on the clinical significance of PGCC, the need for standardized nomenclature and molecular markers, as well as possible avenues to develop therapies aimed at PGCC and the process of neosis. The biology underlying the development of PGCC including cell cycle checkpoint dysregulation, stress responses, dedifferentiation, stemness and epithelial-mesenchymal transition is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|