Selective plasma exchange in ABO-incompatible kidney transplantation: comparison of substitution with albumin and partial substitution with fresh frozen plasma
| Autor: | Toshihide Naganuma, Ako Hanaoka, Junji Uchida, Yoshiaki Takemoto, Tatsuya Nakatani, Daijiro Kabata, Ayumi Shintani |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Transplantation Conditioning Urology 030232 urology & nephrology Serum albumin lcsh:Medicine Serum Albumin Human 030204 cardiovascular system & hematology Fibrinogen Gastroenterology Article ABO Blood-Group System Plasma 03 medical and health sciences 0302 clinical medicine Isoantibodies ABO blood group system Internal medicine medicine Humans lcsh:Science Kidney transplantation Aged Retrospective Studies Multidisciplinary Plasma Exchange biology Renal replacement therapy business.industry lcsh:R Albumin Middle Aged medicine.disease Factor XIII Kidney Transplantation Apheresis biology.protein lcsh:Q Female Fresh frozen plasma business medicine.drug |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-58436-2 |
| Popis: | We have performed selective plasma exchange (SePE) as apheresis before ABO-incompatible kidney transplantation since 2015. In this study, we divided the SePE sessions into two groups, those using albumin alone (Group A) and those partially using fresh frozen plasma (FFP) (Group F), and compared their clinical efficacies. A total of 58 sessions of SePE (Group A: n = 41, Group F: n = 17) were performed in 30 recipients of ABOi kidney transplantation during the study period and the decrease in isoagglutinin titers, changes in the levels of serum IgG and IgM as well as coagulation factors (fibrinogen, factor XIII), and incidence of side effects were retrospectively compared. There was a more significant decrease of isoagglutinin titers in Group F compared to Group A. Immunoglobulins and coagulants were replenished in Group F. Meanwhile, the incidence of side effects was significantly higher in Group F. SePE using FFP, which can effectively decrease isoagglutinins titers and replenish immunoglobulin and coagulation factors, may be a beneficial treatment modality as apheresis before ABO-incompatible kidney transplantation, in spite of a disadvantage that there are many side effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|