Treatment of spasmodic torticollis with local injections of botulinum toxin
| Autor: | Werner Poewe, Günther Deuschl, Matias Wagner, L. Schelosky, Florian Heinen, B. Kleedorfer |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Weakness Botulinum Toxins Spasmodic Torticollis Electromyography medicine.disease_cause Injections Intramuscular medicine Humans Cervical dystonia Torticollis medicine.diagnostic_test business.industry medicine.disease Dysphagia Botulinum toxin Surgery Neurology Anesthesia Clostridium botulinum Female Neurology (clinical) medicine.symptom Deglutition Disorders business Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Neurology. 239:21-25 |
| ISSN: | 1432-1459 0340-5354 |
| DOI: | 10.1007/bf00839206 |
| Popis: | Thirty-seven patients with spasmodic torticollis (cervical dystonia) who received repeated local injections of botulinum toxin have been followed up for a mean period of 12.3 (10–29) months, during which time 138 treatment sessions were performed. Mean doses per muscle averaged 320 mouse units (mu; range 160–1000 mu botulinum toxin A prepared by CAMR, Porton Down, UK). Eighty-six per cent of patients experienced significant improvement of posture and 84% of those with pain had relief following the first injection. Muscular patterns of recurrent torticollis were relatively constant and in most patients efficacy was maintained with subsequent injections, while 15% of all follow-up sessions failed. Only 2 of 37 patients were consistent non-responders; 22% and 10% of all sessions were complicated by transient dysphagia and weakness of neck muscles, respectively. It is concluded that local botulinum toxin injections can be a safe and efficaceous long-term treatment of spasmodic torticollis and that optimal doses should be between 200 and 400 mu/muscle. |
| Databáze: | OpenAIRE |
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