The hamster egg penetration test may decrease intracytoplasmic sperm injection utilization while maintaining high conventional fertilization rates
| Autor: | Erica Johnstone, Benjamin R. Emery, Brett D. Einerson, Yetunde Ibrahim, Douglas T. Carrell |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Urology medicine.medical_treatment sperm penetration assay Hamster intracytoplasmic sperm injection Fertilization in Vitro Biology Semen analysis lcsh:RC870-923 Intracytoplasmic sperm injection World health semen analysis Andrology Human fertilization Cricetinae medicine Animals Humans Sperm Injections Intracytoplasmic Sperm-Ovum Interactions Univariate analysis In vitro fertilisation medicine.diagnostic_test urogenital system conventional fertilization General Medicine lcsh:Diseases of the genitourinary system. Urology Sperm hamster egg penetration test Female Original Article Sperm Capacitation |
| Zdroj: | Asian Journal of Andrology Asian Journal of Andrology, Vol 23, Iss 1, Pp 11-15 (2021) |
| ISSN: | 1745-7262 |
| Popis: | This was a cohort study of in vitro fertilization (IVF) subjects at the University of Utah, Salt Lake City (UT, USA) utilizing partner sperm. Cycles where both the hamster egg penetration test (HEPT) and semen analysis were performed within 2 years prior to IVF cycles were stratified into four groups based on a normal or an abnormal HEPT and morphology. The mean conventional and intracytoplasmic sperm injection (ICSI) fertilization rates were calculated in each group. We performed a univariate analysis on the primary outcome comparing clinically interesting subjects. We performed a cost-effectiveness analysis of a policy of HEPT versus universal ICSI in couples with an abnormal morphology. Among patients with a normal HEPT, there was no difference in the mean conventional fertilization rates between those with a normal and an abnormal morphology. There was no difference in the mean conventional fertilization rates between subjects with a normal morphology without a hamster test and those with a normal HEPT without a morphology assessment. In 1000 simulated cycles with an abnormal morphology, a policy of HEPT was cost saving compared to universal ICSI, yet produced similar fertilization rates. The HEPT is similar to the World Health Organization edition 5 (WHO-5) morphology in predicting successful conventional fertilization while allowing decreased utilization of ICSI. A policy of HEPT for males with abnormal morphology saves cost in selecting couples for a fertilization method. |
| Databáze: | OpenAIRE |
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