Favourable prognostic factors in therapy related acute myeloid leukaemia
| Autor: | Rajko Milosevic, Nebojsa Antonijevic, Tatjana Terzic, Nada Suvajdžić, Ivo Elezovic, Milica Colovic, Gradimir Jankovic, Branko Jakovljevic |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology medicine.medical_treatment lcsh:Medicine Antineoplastic Agents Disease survival 03 medical and health sciences 0302 clinical medicine Bone Marrow hemic and lymphatic diseases Cytology Internal medicine medicine Humans Aged Chemotherapy Therapy related Radiotherapy business.industry lcsh:R Cytogenetics Neoplasms Second Primary Karyotype General Medicine Middle Aged Prognosis medicine.disease Pancytopenia 3. Good health Survival Rate Leukemia Myeloid Acute therapy related acute myeloid leukaemia Dysplasia Karyotyping 030220 oncology & carcinogenesis Cytogenetic Analysis cytology Female myelodysplasia business Granulocytes 030215 immunology |
| Zdroj: | Srpski Arhiv za Celokupno Lekarstvo, Vol 139, Iss 5-6, Pp 347-352 (2011) Srpski arhiv za celokupno lekarstvo (2011) 139(5-6):347-352 |
| ISSN: | 2406-0895 0370-8179 |
| DOI: | 10.2298/sarh1106347a |
| Popis: | Introduction. Therapy related acute myeloid leukaemia (t-AML) is a distinct clinical entity recognized by the World Health Organization classification occurring after chemotherapy and/or radiation treatment administered for a previous disease. T-AML is characterised by pancytopenia, three-lineage myelodysplasia, high frequency of unfavourable cytogenetics and short survival. Objective. The aim of this study was to analyse clinical, cytogenetic, and cytological characteristics of t-AML and their impact on survival. Methods. Seventeen patients with t-AML (8 male and 9 female; median age 59 years) were identified among 730 consecutive patients with acute myeloid leukaemia. The degree of three-lineage dysplasia as well as haematological, cytological and cytogenetic analyses, were assessed by standard methods. Results. The patients survived a median of 62.5 days with the 10% probability of survival during two years. Prognostically favourable factors were a higher percentage of dysplastic granulocytic cells, age less than 60 years, and presence of prognostically favourable karyotype inv(16), t(15;17), t(8;21). Conclusion. The stated prognostic factors that include age, cytogenetics findings and granulocytic dysplasia analysis could contribute to adequate risk stratification of t-AML, though fuller results would require additional analyses. |
| Databáze: | OpenAIRE |
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