Evaluation of plasma adiponectin levels in young men with coronary artery disease
| Autor: | Mehmet Uzun, Cemal Sag, Mehmet Yokuşoğlu, Oben Baysan, Kürşad Erinç, Cem Köz, Adnan Haşimi, Ersoy Isik |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Coronary Disease Plasma adiponectin Statistics Nonparametric Coronary artery disease Predictive Value of Tests Risk Factors Internal medicine Humans Insulin Medicine Young male Adiponectin business.industry General Medicine medicine.disease Lipids Patient population Logistic Models ROC Curve Case-Control Studies Cardiology Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Acta Cardiologica. 62:235-239 |
| ISSN: | 0001-5385 |
| DOI: | 10.2143/ac.62.3.2020811 |
| Popis: | In this study, we investigated the relation between plasma adiponectin levels and other risk factors in a young patient population.We enrolled consecutively 69 young patients (45 years) with coronary artery disease in the study group. he patient enrollment period was between February 2003 and November 2004. The control group consisted of 42 age- and sex-matched healthy subjects. Anthropometric, lipid and other variables including adiponectin, fasting glucose and plasma insulin levels were measured in all subjects. Appropriate statistical analyses were performed to determine the differences between the groups, the relation between adiponectin and other parameters and independent factors that predict CAD. There was a statistically significant difference between the groups in terms of lipid parameters (triglycerides, total cholesterol, HDL and LDL cholesterol). Mean plasma adiponectin levels were significantly lower in the patients (P0.05). Among the risk factors adiponectin had a significant negative association with the plasma triglyceride level (P0.01). Logistic regression analysis revealed triglycerides and adiponectin as independent predictors of CAD. The areas under the ROC curves of adiponectin and triglycerides were not different (P0.05).We found a decreased plasma adiponectin level in young male patients with coronary artery disease. It may be a novel marker of atherosclerosis in young men. |
| Databáze: | OpenAIRE |
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