Assessment of intestinal damage in rotavirus infected neonatal mice by a d-xylose absorption test
| Autor: | L. A. Babiuk, M.I. Sahara, M.K. Ijaz, P.J. Frenchick |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Rotavirus
Ratón Reoviridae Absorption (skin) Xylose medicine.disease_cause Intestinal absorption Article Rotavirus Infections Microbiology chemistry.chemical_compound d-Xylose test Mice Xylose metabolism Species Specificity Reference Values Virology medicine Animals Animal model biology biology.organism_classification Small intestine Intestinal Diseases medicine.anatomical_structure chemistry Intestinal Absorption |
| Zdroj: | Journal of Virological Methods |
| ISSN: | 0166-0934 |
| DOI: | 10.1016/0166-0934(87)90120-0 |
| Popis: | A D-xylose absorption test has been standardized for use in newborn mice. It was used to measure small intestine dysfunction in neonate mice following infection with various isolates of rotaviruses. A xylose dose of 1 mg/g body weight was required to produce a maximum level of 100 micrograms/100 microliters of plasma 2 h after administration of D-xylose. The mice inoculated with rotavirus absorbed significantly less D-xylose compared with uninoculated control mice. A micromethod is described which proved to be suitable to quantitate D-xylose for determination of absorptive function of the small intestine in small animals such as newborn mice. |
| Databáze: | OpenAIRE |
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