Carcinogenic effects of N-nitroso-3-(substituted phenylimino)-indolin-2-one derivatives
| Autor: | Rousso Govindarajan, Kirthiga Ramalingam, Murali Kumarasamy, Scott G. Franzblau, Panneerselvam Theivendren |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Carcinogenic activity
Activity profile Schiff base lcsh:QD71-142 lcsh:Analytical chemistry lcsh:RS1-441 Bioengineering MTT cell-viability assay Indolin 2 one Nitroso Pyrazole Medicinal chemistry General Biochemistry Genetics and Molecular Biology Toxicology N-nitrosoisatin lcsh:Pharmacy and materia medica chemistry.chemical_compound chemistry Proton NMR Amine gas treating Original Article General Pharmacology Toxicology and Pharmaceutics Carcinogen |
| Zdroj: | Journal of Pharmacy and Bioallied Sciences, Vol 4, Iss 3, Pp 207-211 (2012) Journal of Pharmacy & Bioallied Sciences |
| ISSN: | 0976-4879 0975-7406 |
| Popis: | Aim: A novel series of N-nitroso-3-(substituted phenylimino)-indolin-2-one 3a-h was synthesized and tested for carcinogenic effects. Materials and Methods: The synthesized pyrazole derivatives' chemical structures were proved by means of their infra red (IR), proton nuclear magnetic resonance ( 1 H-NMR), and mass,and confirmed by elemental analyses. The carcinogenic activity was assessed by 3-(4,5dimethyl thiazole-2yl)-2,5-diphenyltetrazoliumbromide (MTT) cell-viability assay. Results: The results show that most of the synthesized compounds exhibit significant carcinogenic activities. Among the synthesized compounds, N-nitroso-3-(2,4-dinitrophenylimino)-indolin-2-one 3h exhibited the most potent carcinogenic activity. Conclusion: The structure-activity relationship (SAR) studies show that the nature as well as the position of the amine are important for deciding the activity profile of the indolin-2-one derivatives, which reiterates the need for further experimental investigations. |
| Databáze: | OpenAIRE |
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