Animal venoms: therapeutic tools for tackling Parkinson's disease
| Autor: | Matheus Ferroni Schwartz, Priscilla Galante, Kamila Soares Lopes, Henrique de Oliveira Amaral, Victoria Monge-Fuentes, Márcia Renata Mortari, Luana Cristina Camargo, Andreia Biolchi Mayer, Gabriel Avohay Alves Campos |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Parkinson's disease Central nervous system Drug Evaluation Preclinical Substantia nigra Disease Bioinformatics Neuroprotection Cell Line 03 medical and health sciences 0302 clinical medicine Drug Discovery Medicine Animals Humans Pharmacology Clinical Trials as Topic Drug discovery business.industry Venoms Dopaminergic Parkinson Disease medicine.disease Symptomatic relief Disease Models Animal 030104 developmental biology medicine.anatomical_structure Neuroprotective Agents Treatment Outcome 030220 oncology & carcinogenesis business |
| Zdroj: | Drug discovery today. 24(11) |
| ISSN: | 1878-5832 |
| Popis: | Parkinson's disease (PD) is a neurodegenerative pathology of the central nervous system, mainly involving the selective and progressive loss of dopaminergic neurons from the substantia nigra, resulting in motor and non-motor symptoms. PD remains an incurable ailment; thus, treatments are limited to symptom alleviation. With long-term use, conventional treatments can become inefficient, often triggering possible side effects. Considering these drawbacks, drug discovery constantly turns to nature as a source of efficient therapeutics. Thus, this review explores animal venoms as a rich source of bioactive compounds with potent neuropharmacological profiles for the development of effective adjuvant treatments with fewer side effects, ultimately aiming for the neuroprotection of dopaminergic neurons and the symptomatic relief of PD. |
| Databáze: | OpenAIRE |
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