Evaluation of liver fibrosis using hepatic extracellular volume fraction by contrast-enhanced computed tomography before and after direct-acting antiviral therapy in patients with chronic hepatitis C infection: comparison with serological liver fibrosis markers
| Autor: | Tsutomu Tamada, Atsushi Higaki, Akira Yamamoto, Hidemitsu Sotozono, Kiyoka Maeba, Akihiko Kanki, Kazuya Yasokawa |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Liver Cirrhosis Male Pathology medicine.medical_specialty Liver fibrosis Contrast Media Computed tomography Antiviral Agents Serology Extracellular fluid Humans Medicine Radiology Nuclear Medicine and imaging In patient Aged Retrospective Studies Aged 80 and over Extracellular volume fraction Full Paper medicine.diagnostic_test business.industry Antiviral therapy General Medicine Hepatitis C Chronic Middle Aged Radiographic Image Enhancement Liver Female Extracellular Space Tomography X-Ray Computed business Biomarkers Direct acting |
| Zdroj: | Br J Radiol |
| ISSN: | 1748-880X 0007-1285 |
| DOI: | 10.1259/bjr.20210045 |
| Popis: | Objective: To evaluate time-dependent changes in hepatic extracellular volume (ECV) fraction using contrast-enhanced CT (CECT) and serological liver fibrosis markers, the fibrosis-4 (FIB-4) index and aspartate aminotransferase to platelet ratio index (APRI), before and after direct-acting antiviral therapy (DAA) for hepatitis C virus (HCV) infection. Methods: 41 HCV-infected patients who achieved sustained virological response (SVR) after DAA (SVR group) and 10 control patients (untreated or unresponsive to treatment) who underwent CECT and serum biochemical tests before or after the first examination/DAA (T1) and at intervals thereafter (T2:24 months) were evaluated. Results: In the control group, ECV fractions remained relatively unchanged through the study, and significant differences in FIB-4 index comparisons and APRI comparisons were only seen between the T2 and T4 values (p = 0.046 and p = 0.028, respectively). In the SVR group, ECV fractions were significantly different between T1 and T4 and T1 and T5 (p = 0.046 and 0.022, respectively), and both FIB-4 index and APRI were significantly different between T1 and all other time points (p = 0.017 to p < 0.001 and p = 0.001 to p < 0.001, respectively). Conclusion: After DAA, ECV fraction decreased slowly, suggesting an improvement in hepatic fibrosis, while serological liver fibrosis markers decreased immediately, probably due to improvement in hepatic inflammation. Advances in knowledge: ECV fraction has the potential to be a non-invasive biomarker for the assessment of liver fibrosis after direct-acting antiviral therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|