Self-transformation synthesis of hierarchically porous benzene-bridged organosilica nanoparticles for efficient drug delivery
| Autor: | Xiaodan Su, Lianhui Wang, Wei Lu, Jiajia Zhao, Jun Tao, Muhammad Rizwan Younis, Lixing Weng, Zhihao Feng, Zhaogang Teng, Dong Chen |
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| Rok vydání: | 2021 |
| Předmět: |
Nanostructure
Nanoparticle Benzene Hydrothermal circulation Surfaces Coatings and Films Electronic Optical and Magnetic Materials Biomaterials chemistry.chemical_compound Drug Liberation Colloid and Surface Chemistry Drug Delivery Systems chemistry Chemical engineering Pharmaceutical Preparations Photochemotherapy Doxorubicin Cell Line Tumor Drug delivery Humans Nanoparticles Photosensitizer Mesoporous material Porosity |
| Zdroj: | Journal of colloid and interface science. 608(Pt 2) |
| ISSN: | 1095-7103 |
| Popis: | Herein, a feasible outside-in hydrothermal self-transformation strategy is presented to fabricate hierarchically porous benzene-bridged organosilica nanoparticles (HPBONs), and detailed mechanistic investigations were performed to study the formation of hierarchically porous nanostructures. The obtained HPBONs consisted of a mesoporous core (2.3 nm) and a large mesoporous flocculent shell (12.6 nm), which corresponded to an overall diameter of ∼ 200 nm and good water dispersibility, respectively. Owing to the unique hierarchically porous structure and high surface area (877 m2/g), HPBONs showed a high coloading capacity for the hydrophilic drug doxorubicin (DOX) and the hydrophobic photosensitizer chlorin e6 (Ce6) (355 µg/mg, 38 µg/mg, respectively) and acid-responsive DOX drug release (42.62%), leading to precise chemo-photodynamic therapy in vitro, as the cytotoxicity assay revealed 70% killing of breast cancer (MCF-7) cells. This research provides a new method to construct hierarchically porous organosilica-based nanodelivery systems. |
| Databáze: | OpenAIRE |
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