Telocytes in liver: electron microscopic and immunofluorescent evidence
| Autor: | Fei Wang, Changqing Yang, Zhenguo Liu, Junjie Xiao |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology medicine.medical_specialty Receptor Platelet-Derived Growth Factor alpha CD34 Fluorescent Antibody Technique Antigens CD34 Vimentin Biology telocytes liver Immunofluorescence Mice symbols.namesake vimentin Microscopy Electron Transmission Telocyte medicine Animals hepatic putative stem cells Progenitor telopodes medicine.diagnostic_test CD117 Regeneration (biology) fungi Original Articles Cell Biology Interstitial Cells of Cajal Interstitial cell of Cajal Mice Inbred C57BL Proto-Oncogene Proteins c-kit c-kit biology.protein symbols Molecular Medicine PDGFR-α β |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 1582-1838 |
| DOI: | 10.1111/jcmm.12195 |
| Popis: | Hepatic interstitial cells play a vital role in regulating essential biological processes of the liver. Telocytes (TCs), a novel type of interstitial cells firstly identified by Popescu and his coworkers, have been reported in many tissues and organs, but not yet in liver (go to http://www.telocytes.com). We used transmission electron microscopy and immunofluorescence (double labelling for CD34 and c-kit/CD117, or vimentin, or PDGF Receptor-α, or β) to provide evidence for the existence of TCs in mice liver. The distribution of TCs in liver was found to be of similar density in the four hepatic lobes. In conclusion, here we show the presence of TCs in mice liver. It remains to be determined the possible roles of TCs in the control of liver homeostasis and regeneration, the more so as a close special relationship was found between TCs and hepatic putative stem (progenitor) cells. |
| Databáze: | OpenAIRE |
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