Genetic polymorphisms in TNIP1 increase the risk of gastric carcinoma
| Autor: | Hua Yang, Xiyang Zhang, Qi Zhang, Yiming Li, Yuyan Na, Yuting Shi, Tianbo Jin, Xianglong Duan, Zhao Liu, Sizhe Cao |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine China medicine.medical_specialty Pathology Genotype case-control study Zhàng Protective factor Gastric carcinoma Polymorphism Single Nucleotide Gastroenterology Linkage Disequilibrium 03 medical and health sciences 0302 clinical medicine Asian People Gene Frequency Risk Factors Stomach Neoplasms Internal medicine Genetic variation Odds Ratio Humans Medicine Genetic Predisposition to Disease gastric carcinoma Alleles Aged business.industry TNIP1 gene Carcinoma Haplotype Case-control study TNF-α-induced protein 3-interacting protein 1 (TNIP1) single nucleotide polymorphisms (SNPs) Middle Aged DNA-Binding Proteins 030104 developmental biology Haplotypes Oncology Case-Control Studies 030220 oncology & carcinogenesis Female business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | The distribution and levels of TNIP1 in malignant and normal gastric mucosa are different, but it is not known whether TNIP1 polymorphisms are related to gastric carcinogenesis. To assess the association between four TNIP1 SNPs (rs3792792, rs4958881, rs7708392, rs10036748) and carcinogenesis, we used Sequenom Mass-ARRAY technology to determine the genotypes of 302 gastric carcinoma patients and 300 healthy controls in a Northwest Chinese Han population. These data were then compared using the Chi-square test/Fisher's exact test, genetic model analysis, and haplotype analysis. Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate the correlation. We observed that patients with the “G” allele of rs7708392 and the “C” allele of rs10036748 showed an increased risk of gastric carcinoma (OR= 1.335, 95%CI: 1.021-1.745, P= 0.035; OR= 1.358, 95%CI: 1.039-1.774, P= 0.025, respectively). Conversely, the haplotype “CT” of TNIP1 (rs7708392-rs10036748) may act as a genetic protective factor for gastric carcinoma (adjusted OR= 0.731, 95%CI: 0.552-0.970, P= 0.030). Our results are the first to suggest that genetic variation in TNIP1 gene is associated with gastric carcinoma, though, this finding must be confirmed in other populations with larger sample size. |
| Databáze: | OpenAIRE |
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