Development of Autoimmune Hepatitis during Direct-acting Antiviral Therapy for Chronic Hepatitis C Virus Infection
| Autor: | Kentaro Kikuchi, Shinpei Doi, Yuichi Takano, Kotaro Matsumoto, Koichiro Sato, Yusuke Kajiyama, Hiroshi Miyakawa, Ichiro Yasuda, Masatoshi Mabuchi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Biopsy
Case Report Autoimmune hepatitis Antiviral Agents Virus 03 medical and health sciences 0302 clinical medicine Chronic hepatitis Quinoxalines Internal Medicine medicine Humans direct-acting antivirals Benzofurans Liver injury Aged 80 and over biology medicine.diagnostic_test autoimmune hepatitis business.industry chronic hepatitis C virus infection Imidazoles prednisolone General Medicine Hepatitis C Chronic medicine.disease digestive system diseases Drug Combinations Hepatitis Autoimmune Liver 030220 oncology & carcinogenesis Liver biopsy Antibodies Antinuclear Immunology Prednisolone biology.protein 030211 gastroenterology & hepatology Female Antibody Differential diagnosis Chemical and Drug Induced Liver Injury business medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | An 81-year-old woman developed liver dysfunction after two months' treatment with direct-acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection. She was positive for serum anti-nuclear antibody, with an elevated immunoglobulin G level. A liver biopsy revealed high-grade interface hepatitis and infiltrate of lymphocytes and plasma cells. DAA-associated drug-induced autoimmune hepatitis (DI-AIH) was considered. Her liver dysfunction improved after discontinuing DAA therapy and starting prednisolone treatment. The differential diagnosis for AIH should include liver injury during DAA therapy for chronic HCV infection. |
| Databáze: | OpenAIRE |
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