Simple methods for the synthesis of N-substituted acryl amides using Na2CO3/SiO2 or NaHSO4/SiO2
| Autor: | Mamiko Hayakawa, Kenshiro Tashiro, Daiki Sumiya, Tadashi Aoyama |
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| Rok vydání: | 2023 |
| Předmět: | |
| DOI: | 10.6084/m9.figshare.22642844 |
| Popis: | A simple and efficient procedure for the synthesis of N-substituted acryl amides has been developed using Na2CO3/SiO2 or NaHSO4/SiO2. Na2CO3/SiO2 smoothly acts as a base in the reaction between acryloyl chloride and a variety of amines to obtain their corresponding products in good to excellent yield. Additionally, NaHSO4/SiO2 catalyzed the Ritter reaction between acryl nitrile and sec-benzylic alcohols to give the expected N-substituted acryl amide product. In both reactions, Na2CO3/SiO2 and NaHSO4/SiO2 were removed from the reaction mixture using filtration. |
| Databáze: | OpenAIRE |
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