Hypothermia alleviated LPS-induced acute lung injury in Rat models through TLR2/MyD88 pathway
| Autor: | Juntao Hu, Jie Lai, Yun-Xia Zhou, Liangyan Jiang, Xianfeng Chen, Zhanhong Tang, Bing Zhou, Chi Zhang, Wei Zhou, Yiping Pan |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Lipopolysaccharides Lipopolysaccharide Clinical Biochemistry Acute Lung Injury Inflammation Pharmacology Lung injury 03 medical and health sciences chemistry.chemical_compound Hypothermia Induced Medicine Animals Molecular Biology Pathological business.industry respiratory system Hypothermia Toll-Like Receptor 2 respiratory tract diseases Rats TLR2 030104 developmental biology chemistry Myeloid Differentiation Factor 88 Tumor necrosis factor alpha medicine.symptom business Plasminogen activator Signal Transduction |
| Zdroj: | Experimental lung research. 44(8-9) |
| ISSN: | 1521-0499 |
| Popis: | Acute lung injury (ALI) is a common clinical syndrome in ICU departments with high mortality. The pathology of ALI is still not clear and there is no specific and efficient treatment against ALI. In this study, we established ALI rat model through lipopolysaccharide administration. We found that hypothermia therapy led to significant improvement in oxygenation index, edema formation and pathological score, demonstrating that hypothermia is beneficial to the recovery of lung function and alleviation of lung injury. Besides, hypothermia resulted in a decrease in plasminogen activator inhibitor-1(PAI-1) concentration, showing the inflammation was partially inhibited. This was also confirmed by a decrease in TNF-α mRNA and protein level in hypothermia group. The effect of hypothermia was mediated by TLR2/MyD88 signaling, which led to the alteration in NF-κB p65 level. Collectively, this study indicated that hypothermia therapy was potentially an efficient therapy against ALI. |
| Databáze: | OpenAIRE |
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