Effects of hyperglycaemia on ocular development in rabbit: refraction and biometric changes
| Autor: | Peter Herse |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Blood Glucose
Male Chronic hyperglycaemia medicine.medical_specialty Time Factors endocrine system diseases Eye Refraction Ocular Diabetes Mellitus Experimental Acute onset Lens thickness Ophthalmology Diabetes mellitus Lens Crystalline Animals Medicine Retinoscopy medicine.diagnostic_test business.industry nutritional and metabolic diseases medicine.disease Refraction Sensory Systems Surgery Acute hyperglycaemia medicine.anatomical_structure Lens (anatomy) Acute Disease Chronic Disease Rabbits sense organs business Optometry |
| Zdroj: | Ophthalmic and Physiological Optics. 25:97-104 |
| ISSN: | 1475-1313 0275-5408 |
| DOI: | 10.1111/j.1475-1313.2004.00262.x |
| Popis: | Aim: To determine the effect of acute and chronic hyperglycaemia on the refraction and development of the rabbit eye. Methods: Ocular dimensions of five alloxan-induced hyperglycaemic and six control rabbits were measured over 9 weeks using A scan biometry. Refraction was measured using retinoscopy. The animals were 10 weeks of age at the start of the experiment. Results: The acute onset of hyperglycaemia was associated with a fast and stable 2 D hyperopic shift in refraction. Lens thickness increased during the first 2 weeks of hyperglycaemia, returned to near normal thickness after 3–5 weeks of hyperglycaemia and then decreased in thickness in the last 4 weeks of the study. The hyperopic refraction remained unchanged during changes in lens thickness. Nine weeks of hyperglycaemia was associated with a 25% reduction in the growth of both the globe and the lens and a 17% decrease in body mass compared with the controls. Conclusion: The hyperopic refraction change of acute hyperglycaemia is likely to be because of a change in the refractive index of the cortical fibres of the lens and is the probable source of the fluctuating refraction seen in diabetic patients. Chronic hyperglycaemia reduced the axial development of the eye and is the probable source of the chronic hyperopic refraction seen in children with Type I diabetes. |
| Databáze: | OpenAIRE |
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