Selective inhibition of histone deacetylase 3 by novel hydrazide based small molecules as therapeutic intervention for the treatment of cancer

Autor:	Sravani Pulya, Tarun Patel, Milan Paul, Nilanjan Adhikari, Suvankar Banerjee, Ganesh Routholla, Swati Biswas, Tarun Jha, Balaram Ghosh
Rok vydání:	2022
Předmět:	Pharmacology Organic Chemistry Antineoplastic Agents Apoptosis Histone Deacetylase 1 General Medicine Histone Deacetylases Histone Deacetylase Inhibitors Mice Hydrazines Cell Line Tumor Neoplasms Drug Discovery Animals Humans Cell Proliferation
Zdroj:	European Journal of Medicinal Chemistry. 238:114470
ISSN:	0223-5234
Popis:	A promising hydrazide based small molecule lead as a potent and selective histone deacetylase 3 (HDAC3) inhibitor has been developed from a small series of synthesized novel chemical entities. The lead compound (4e) displayed high HDAC3 inhibitory potency (IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af5ffd75e63adcbaac3c5f6ba4db37e https://doi.org/10.1016/j.ejmech.2022.114470 Zobrazit plný text záznamu Full Text from ScienceDirect