Genomics Links Inflammation With Neurocognitive Impairment in Children Living With Human Immunodeficiency Virus Type-1

Autor:	George R. Seage, Kelly A. Frazer, Sharon Nichols, Stephen A. Spector, Jihoon Kim, Pratima Rawat, Rodney N. Trout, Russell B. Van Dyke, Paige L. Williams, Sean S Brummel, Kumud K. Singh, Olivier Harismendy
Rok vydání:	2020
Předmět:	Male 0301 basic medicine Oncology medicine.medical_specialty Inflammasomes Neurocognitive Disorders HIV Infections Inflammation Logistic regression Receptors CCR Major Articles and Brief Reports 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Immunology and Allergy Gene silencing Child Exome sequencing Gene knockdown business.industry Intracellular Signaling Peptides and Proteins Infant Membrane Proteins Genomics Odds ratio Infectious Disease Transmission Vertical 030104 developmental biology Infectious Diseases 14-3-3 Proteins Child Preschool Cohort HIV-1 Female Microglia medicine.symptom business Neurocognitive 030217 neurology & neurosurgery Genome-Wide Association Study
Zdroj:	J Infect Dis
ISSN:	1537-6613 0022-1899
Popis:	Background We identified host single-nucleotide variants (SNVs) associated with neurocognitive impairment (NCI) in perinatally HIV-infected (PHIV) children. Methods Whole-exome sequencing (WES) was performed on 217 PHIV with cognitive score for age (CSA) Results Twenty-nine SNVs in 24 genes reaching P ≤ .002 and OR ≥ 1.5 comparing CSA Conclusions Using WES and 2 VCs, and gene silencing of microglia we identified 3 genetic variants associated with NCI and inflammation in HIV-infected children.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af40e28112313e7b469fbec806fc9e5 https://doi.org/10.1093/infdis/jiaa792 Zobrazit plný text záznamu