The Importance of Epigenetics in Diagnostics and Treatment of Major Depressive Disorder
| Autor: | Tomasz Sliwinski, Justyna Strycharz, Gabriela Barszczewska, Piotr Czarny, Katarzyna Bialek, Sylwia Ziolkowska |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Medicine (miscellaneous)
lcsh:Medicine Review Disease Bioinformatics 03 medical and health sciences 0302 clinical medicine histones microRNA Medicine Epigenetics 030304 developmental biology 0303 health sciences DNA methylation long non-coding RNA biology epigenetics business.industry histone modifications lcsh:R personalized medicine medicine.disease Histone depression biology.protein Major depressive disorder Antidepressant Personalized medicine business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Personalized Medicine, Vol 11, Iss 167, p 167 (2021) Journal of Personalized Medicine |
| ISSN: | 2075-4426 |
| Popis: | Recent studies imply that there is a tight association between epigenetics and a molecular mechanism of major depressive disorder (MDD). Epigenetic modifications, i.e., DNA methylation, post-translational histone modification and interference of microRNA (miRNA) or long non-coding RNA (lncRNA), are able to influence the severity of the disease and the outcome of the therapy. This article summarizes the most recent literature data on this topic, i.e., usage of histone deacetylases as therapeutic agents with an antidepressant effect and miRNAs or lncRNAs as markers of depression. Due to the noteworthy potential of the role of epigenetics in MDD diagnostics and therapy, we have gathered the most relevant data in this area. |
| Databáze: | OpenAIRE |
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