Pathogenomics analysis of Leishmania spp.: flagellar gene families of putative virulence factors
| Autor: | Luis A.C. Costa, Cezar A. Walter, Jose O. Faria, Ana Carolina Landim Pacheco, Nilo Batista Diniz, Adriana da Rocha Tomé, J. J. S. Gouveia, Allan R.S. Maia, Sônia Maria Pinheiro de Oliveira, Michely C. Diniz, Marcos Jose N. Gomes, Diana Oliveira, Marianna C. Albuquerque, Maria Cristina da Silva, Rodrigo Maggioni, Raimundo Bezerra da Costa, Elton J R Vasconcelos, João Osmar P. Melo, Thiago D. Ferreira, Daniel de Araújo Viana, Daniel C. Fortier, R. Araujo-Filho |
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| Rok vydání: | 2005 |
| Předmět: |
Proteome
Genes Protozoan Molecular Sequence Data Protozoan Proteins Virulence Flagellum Biochemistry Genome Pathogenomics parasitic diseases Databases Genetic Genetics Animals Leishmania major Amino Acid Sequence Molecular Biology Gene Leishmania biology Sequence Homology Amino Acid biology.organism_classification Cell biology Flagella Multigene Family Molecular Medicine Genome Protozoan Biotechnology |
| Zdroj: | ResearcherID |
| ISSN: | 1536-2310 |
| Popis: | The trypanosomatid flagellar apparatus contains conventional and unique features, whose roles in infectivity are still enigmatic. Although the flagellum and the flagellar pocket are critical organelles responsible for all vesicular trafficking between the cytoplasm and cell surface, still very little is known about their roles in pathogenesis and how molecules get to and from the flagellar pocket. The ongoing analysis of the genome sequences and proteome profiles of Leishmania major and L infantum, Trypanosoma cruzi, T. brucei, and T. gambiensi ( www.genedb.org ), coupled with our own work on L. chagasi (as part of the Brazilian Northeast Genome Program- www.progene.ufpe.br ), prompted us to scrutinize flagellar genes and proteins of Leishmania spp. promastigotes that could be virulence factors in leishmaniasis. We have identified some overlooked parasite factors such as the MNUDC-1 (a protein involved in nuclear development and genomic fusion) and SQS (an enzyme of sterol biosynthesis), among the described flagellar gene families. A database concerning the results of this work, as well as of other studies of Leishmania and its organelles, is available at http://nugen.lcc.uece.br/LPGate . It will serve as a convenient bioinformatics resource on genomics and pathology of the etiological agents of leishmaniasis. |
| Databáze: | OpenAIRE |
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