Toenail concentrations of trace elements and occupational history in pancreatic cancer

Autor: Joan Alguacil, Magda Gasull, Pere Sanz-Gallén, George L. Delclos, Judit Camargo, José Pumarega, Miquel Porta, Andre F.S. Amaral
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
010504 meteorology & atmospheric sciences
Formaldehyde
chemistry.chemical_element
010501 environmental sciences
01 natural sciences
Risk Assessment
Arsenic
chemistry.chemical_compound
Occupational Exposure
MD Multidisciplinary
Hydrocarbons
Chlorinated
Humans
Pesticides
Polycyclic Aromatic Hydrocarbons
Inductively coupled plasma mass spectrometry
lcsh:Environmental sciences
Occupational Health
0105 earth and related environmental sciences
General Environmental Science
Aged
chemistry.chemical_classification
lcsh:GE1-350
Cadmium
Trace elements
Manganese
Occupation
Pancreatic càncer
Pancreatic cancer
Pesticide
Middle Aged
Cáncer
Trace Elements
Pancreatic Neoplasms
Páncreas
chemistry
Nails
Environmental chemistry
Exocrine pancreatic cancer
Female
Aromatic hydrocarbon
Selenium
Environmental Sciences
Zdroj: Arias Montano. Repositorio Institucional de la Universidad de Huelva
instname
Recercat. Dipósit de la Recerca de Catalunya
Environment International, Vol 127, Iss, Pp 216-225 (2019)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
DOI: 10.1016/j.envint.2019.03.037
Popis: Background: Some occupations potentially entailing exposure to cadmium, arsenic, lead, selenium, nickel, and chromium have been associated with an increased risk of exocrine pancreatic cancer (EPC), but no studies have assessed whether body concentrations of such compounds differed among subjects occupationally exposed and unexposed. No studies which found that exposure to such metals increased the risk of EPC assessed whether past occupations were the source of exposure. Objective: The aim was to analyse the relationship between toenail concentrations of trace elements and occupational history in EPC patients. Methods: The study included 114 EPC cases personally interviewed on occupational history and lifestyle factors. Occupations were coded according to the International Standard Classification of Occupations 1988. Selected occupational exposures were assessed by two industrial hygienists and with the Finnish job-exposure matrix (Finjem). Concentrations of 12 trace elements were determined in toenail samples by inductively coupled plasma mass spectrometry. Adjusted geometric means (aGMs) and 95% confidence intervals (95% CI) were calculated. Results: Patients occupationally exposed to aromatic hydrocarbon solvents (AHs) had higher concentrations of cadmium, manganese, lead, iron and vanadium. The aGM of cadmium concentrations for cases exposed to any pesticide was 0.056 μg/g [95% CI: 0.029–0.108], and, for unexposed cases, 0.023 μg/g [0.017–0.031]. Patients occupationally exposed to pesticides had higher concentrations of cadmium and manganese. Higher concentrations of vanadium, lead and arsenic were related to exposure to formaldehyde. Vanadium and lead were also associated with exposure to chlorinated hydrocarbon solvents, and arsenic was related to exposure to polycyclic aromatic hydrocarbons (PAHs). Conclusions: Patients occupationally exposed to AHs, pesticides, chlorinated hydrocarbon solvents, formaldehyde, volatile sulphur compounds and PAHs had higher concentrations of several metals. These elements may account for some of the occupational risks previously reported for pancreatic cancer.
This work was partly supported by research grants from Instituto de Salud Carlos III, Ministry of Health, Government of Spain (FIS PI13/00020, FIS PI17/00088, and CIBER de Epidemiologia y Salud Publica - CIBERESP); the Hospital del Mar Medical Research Institute (IMIM), Barcelona; Fundacio La Marato de TV3 (20132910); and the Government of Catalonia (2009 SGR 1350, 2014 SGR 1012, 2017 SGR 439). The Dartmouth Trace Element Core was partially supported by NIH Grant Number P42 ES007373 from the National Institute of Environmental Health Sciences.
Databáze: OpenAIRE
Externí odkaz: