Estrogen agonistic/antagonistic activity of brominated parabens
| Autor: | Masanori Terasaki, Kohei Sasaki |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Agonist Halogenation medicine.drug_class Health Toxicology and Mutagenesis Parabens Estrogen receptor 010501 environmental sciences Pharmacology 01 natural sciences Benzylparaben 03 medical and health sciences chemistry.chemical_compound Two-Hybrid System Techniques medicine Agonistic behaviour Humans Environmental Chemistry 0105 earth and related environmental sciences Butylparaben Chemistry Estrogen Receptor alpha Antagonist Estrogens General Medicine Transfection Pollution Tamoxifen 030104 developmental biology Estrogen Protein Binding |
| Zdroj: | Environmental Science and Pollution Research. 25:21257-21266 |
| ISSN: | 1614-7499 0944-1344 |
| DOI: | 10.1007/s11356-018-2600-3 |
| Popis: | The estrogen agonistic/antagonistic activity of 16 brominated by-products of parabens was assessed by using a yeast two-hybrid assay transfected with the human estrogen receptor α. Characterization of synthetic compounds including novel brominated parabens was performed using 1H-NMR spectroscopy and high-resolution mass spectrometry. For the agonist assay, five C3–C4 alkylparabens exhibited significant activity (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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