p53 and cyclin D1 staining patterns of malignant and premalignant oral lesions in age-dependent populations
| Autor: | F. James Kratochvil, James T. Castle, Susan L. Abbondanzo, Harvey P. Kessler, Massimo Cardinali, Paul L. Auclair, W. Andrew Yeudall |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Population medicine.disease_cause Immunoenzyme Techniques Cyclin D1 Carcinoma Humans Medicine education General Dentistry Aged education.field_of_study Chi-Square Distribution business.industry Age Factors Cancer Middle Aged medicine.disease Neoplasm Proteins Staining Otorhinolaryngology Epidermoid carcinoma Carcinoma Squamous Cell Immunohistochemistry Female Mouth Neoplasms Surgery Tumor Suppressor Protein p53 Oral Surgery business Carcinogenesis Precancerous Conditions |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 88:326-332 |
| ISSN: | 1079-2104 |
| Popis: | Objective. Recent epidemiologic studies have identified a trend of increasing cancer incidence in younger patients. The purpose of this study was to determine whether this might be reflected by different molecular mechanisms for tumor development. Study Design. Dysplastic and malignant oral lesions from age-distinct patient populations were immunohistochemically analyzed for expression of p53 and cyclin D1. Chi-square analysis was used to determine statistical significance. Results. Eighty-two percent of “older” and 75% of “younger” carcinomas stained positively with p53; 63% of carcinomas in the older population and 55% of carcinomas in the younger population showed cyclin D1 positivity. Dysplasias showed similar cyclin D1 staining in both groups. Interestingly, 100% of “younger” dysplasias stained positively for p53, whereas 35.3% of “older” dysplastic lesions showed immunoreactivity. Staining of carcinomas was not statistically significant, whereas p53 staining of dysplasias proved highly significant (P < .025). Conclusions. p53 immunoreactivity is detectable at an earlier stage of carcinogenesis in younger patients than in the traditional risk population for oral cancer. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88:326-32) |
| Databáze: | OpenAIRE |
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