Association of Clinical Signs and Symptoms with Bacterial Findings in Acute Otitis Media
| Autor: | Pekka Karma, Terhi Kilpi, Herva E, Heljä Savolainen, P. Helena Mäkelä, Arto A. Palmu |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Microbiology (medical) medicine.medical_specialty medicine.medical_treatment medicine.disease_cause Haemophilus influenzae Pneumococcal Vaccines Myringotomy Moraxella catarrhalis 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests 030225 pediatrics Internal medicine Moraxella (Branhamella) catarrhalis Streptococcus pneumoniae otorhinolaryngologic diseases Humans Medicine Hepatitis B Vaccines 030212 general & internal medicine Child Respiratory tract infections biology business.industry Vaccine trial biology.organism_classification 3. Good health Otitis Media Infectious Diseases Otitis Acute Disease Immunology Female medicine.symptom business |
| Zdroj: | Clinical Infectious Diseases. 38:234-242 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/380642 |
| Popis: | In acute otitis media (AOM), a means of prediction of the bacterial pathogen based on symptoms and signs would be valuable in selecting appropriate antimicrobial treatment. Children in the control arm (n=831) in the Finnish Otitis Media Vaccine Trial were prospectively observed in a study clinic setting from the age of 2 to 24 months. In patients with AOM, myringotomy with aspiration was performed, and middle ear fluid samples were cultured for bacterial pathogens. Symptoms and signs of respiratory infections were thoroughly recorded. Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae were the most common bacterial pathogens. Pneumococcal AOM was associated with more-severe AOM characterized by fever and earache. AOM due to H. influenzae was associated with eye symptoms and findings. Accurate prediction of a bacterial cause of infection based on symptoms and signs of AOM was not possible, but a specific cause was predicted in some situations, with a high probability of applicability to clinical practice. |
| Databáze: | OpenAIRE |
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