Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study
| Autor: | Barry L. Sharaf, Wendy Y. Craig, Richard Holubkov, Dennis M. McNamara, Steven E. Reis, George Sopko, M. Ilyas Kamboh, Qi Chen, Candace M. Kammerer, C. Noel Bairey Merz, Daniel F. Pauly |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Apolipoprotein E
Candidate gene medicine.medical_specialty Genotype QD415-436 Polymorphism Single Nucleotide Biochemistry Antibodies Coronary artery disease Endocrinology Apolipoproteins E Antigens CD Internal medicine Cholesterylester transfer protein medicine OLR1 Humans genetics Apolipoproteins A biology Coronary Stenosis Cell Biology Middle Aged medicine.disease Scavenger Receptors Class E anti-oxLDL antibodies PON1 Cholesterol Ester Transfer Proteins Lipoproteins LDL Stenosis Lipoprotein Lipase Immunoglobulin M Apolipoprotein A-V Immunoglobulin G biology.protein Regression Analysis Female lipids (amino acids peptides and proteins) Patient-Oriented and Epidemiological Research low density lipoprotein Low Density Lipoprotein Receptor-Related Protein-1 |
| Zdroj: | Journal of Lipid Research, Vol 52, Iss 4, Pp 801-807 (2011) |
| ISSN: | 0022-2275 |
| Popis: | Atherosclerosis is the major cause of coronary artery disease (CAD), and oxidized LDL (oxLDL) is believed to play a key role in the initiation of the atherosclerotic process. Recent studies show that inflammation and autoimmune reactions are also relevant in atherosclerosis. In this study, we examined the association of antibodies against oxLDL (anti-oxLDL) with the severity of CAD in 558 Women's Ischemia Syndrome Evaluation (WISE) study samples (465 whites; 93 blacks) determined by coronary stenosis (50% stenosis). We also examined the relationship of anti-oxLDL with serum lipid levels and nine candidate genes including APOE, APOH, APOA5, LPL, LRP1, HL, CETP, PON1, and OLR1. IgM anti-oxLDL levels were significantly higher in the >20% stenosis group than in the ≥20% stenosis group in whites (0.69 ± 0.02 vs. 0.64 ± 0.01, respectively; P = 0.02). IgM anti-oxLDL levels correlated significantly with total cholesterol (r2 = 0.01; P = 0.03) and LDL cholesterol (r2 = 0.017; P = 0.004) in whites. Multiple regression analysis revealed a suggestive association of LPL/S447X single-nucleotide polymorphism (SNP) with both IgG anti-oxLDL (P = 0.02) and IgM anti-oxLDL (P = 0.07), as well as between IgM anti-oxLDL and the OLR1/3′UTR SNP (P = 0.020). Our data suggest that higher IgM anti-oxLDL levels may provide protection against coronary stenosis and that genetic variation in some candidate genes are determinants of anti-oxLDL levels. |
| Databáze: | OpenAIRE |
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