Total mandibulectomy defect in the setting of chronic bisphosphonate use
| Autor: | Steven Mudrovich, Arvind Badhey, Ameya A. Jategaonkar, Sameep Kadakia, Yadranko Ducic, Mofiyinfolu Sokoya |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Modern medicine medicine.medical_treatment Mandibular Osteotomy Mandibular osteotomy 03 medical and health sciences 0302 clinical medicine medicine Humans Mandibular Diseases Debridement Bone Density Conservation Agents Diphosphonates business.industry Osteonecrosis Mandible 030206 dentistry Fibula flap Middle Aged Bisphosphonate Surgery Mandibulectomy Otorhinolaryngology 030220 oncology & carcinogenesis business Total mandibulectomy |
| Zdroj: | American Journal of Otolaryngology. 39:649-651 |
| ISSN: | 0196-0709 |
| DOI: | 10.1016/j.amjoto.2018.05.004 |
| Popis: | Bisphosphonates are among several drugs known in modern medicine to have a potentially deleterious effect on the mandible with chronic use. While purportedly causing a necrotic reaction in the bone, the complete mechanism is not fully elucidated yet as cases are quite rare in the general public. Despite the esoteric nature of this entity, patients suffering from bisphosphonate induced necrosis have a complicated and prolonged course often involving varying degrees of mandibular debridement with severe cases requiring reconstruction. In this report, we present the unique case of a patient with a progressive mandibular osteonecrosis requiring complete mandibulectomy and fibula flap reconstruction. |
| Databáze: | OpenAIRE |
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