BDNF-Met polymorphism and amyloid-beta in relation to cognitive decline in cognitively normal elderly: the SCIENCe project
| Autor: | Niels D. Prins, Karlijn A. van den Bosch, Philip Scheltens, Iris E. Jansen, Inge M.W. Verberk, Jarith L. Ebenau, Wiesje M. van der Flier, Charlotte E. Teunissen, Sven J. van der Lee |
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| Přispěvatelé: | VUmc - School of Medical Sciences, Complex Trait Genetics, Clinical chemistry, Neurology, Amsterdam Neuroscience - Neurodegeneration, Human genetics, Amsterdam Neuroscience - Neuroinfection & -inflammation, APH - Personalized Medicine, APH - Methodology |
| Rok vydání: | 2021 |
| Předmět: |
Male
Risk medicine.medical_specialty Aging Amyloid beta Cognitive Dysfunction/genetics Cerebrospinal fluid Cognition Genetic Neurotrophic factors Polymorphism (computer science) Alzheimer Disease Internal medicine Aging/genetics Medicine Dementia Humans Cognitive Dysfunction Cognitive decline Polymorphism Aged Alzheimer Disease/genetics Amyloid beta-Peptides Polymorphism Genetic biology business.industry Proportional hazards model Dementia/genetics General Neuroscience Brain-Derived Neurotrophic Factor Middle Aged medicine.disease Amyloid beta-Peptides/cerebrospinal fluid Endocrinology biology.protein Female Neurology (clinical) Geriatrics and Gerontology business Brain-Derived Neurotrophic Factor/blood Developmental Biology |
| Zdroj: | van den Bosch, K A, Verberk, I M W, Ebenau, J L, van der Lee, S J, Jansen, I E, Prins, N D, Scheltens, P, Teunissen, C E & Van der Flier, W M 2021, ' BDNF-Met polymorphism and amyloid-beta in relation to cognitive decline in cognitively normal elderly : the SCIENCe project ', Neurobiology of Aging, vol. 108, pp. 146-154 . https://doi.org/10.1016/j.neurobiolaging.2021.08.018 Neurobiology of Aging, 108, 146-154. Elsevier Inc. van den Bosch, K A, Verberk, I M W, Ebenau, J L, van der Lee, S J, Jansen, I E, Prins, N D, Scheltens, P, Teunissen, C E & van der Flier, W M 2021, ' BDNF-Met polymorphism and amyloid-beta in relation to cognitive decline in cognitively normal elderly : the SCIENCe project ', Neurobiology of Aging, vol. 108, pp. 146-154 . https://doi.org/10.1016/j.neurobiolaging.2021.08.018 |
| ISSN: | 1558-1497 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2021.08.018 |
| Popis: | Brain-derived neurotrophic factor (BNDF) plays a role in synapse integrity. We investigated in 398 cognitively normal adults (60±8years, 41% female, MMSE=28±1) the joint association of the Val66Met polymorphism of the BDNF gene (Met+/-) and plasma BDNF levels and abnormal cerebrospinal fluid (CSF) amyloid-beta status (A+/-) with cognitive decline and dementia risk. Age-, sex- and education-adjusted linear mixed models showed that compared to Met-A-, Met+A+ showed steeper decline on tests of global cognition, memory, language, attention and executive functioning, while Met-A+ showed steeper decline on a smaller number of tests. There were no associations between Met+A- and cognitive decline. Cox models showed that compared to Met-A-, Met+A+ participants were at increased risk of dementia (HR=8.8, 95%CI: 2.8–27.9), as were Met-A+ participants (HR=6.5, 95%CI: 2.2–19.5). Lower plasma BDNF was associated with an increased risk of progression to dementia in the A+ participants. Our results imply that Met-carriage on top of amyloid-beta pathology might increase rate of cognitive decline to dementia. |
| Databáze: | OpenAIRE |
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