Synergistic effect of metformin and EGFR-TKI in the treatment of non-small cell lung cancer
| Autor: | Dongfeng Shan, Yanan Li, Haocheng Wang, Xue Yang, Yang Sun, Zhuang Yu, Ya Dong |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Combination therapy medicine.medical_treatment Drug resistance Review Article Epidermal growth factor receptor-tyrosine kinase inhibitor resistance (EFGR-TKI resistance) 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Radiology Nuclear Medicine and imaging Epidermal growth factor receptor Lung cancer Chemotherapy Lung biology business.industry Type 2 Diabetes Mellitus medicine.disease Metformin respiratory tract diseases non-small cell lung cancer (NSCLC) medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein 030211 gastroenterology & hepatology business metformin medicine.drug |
| Zdroj: | Translational Cancer Research |
| ISSN: | 2219-6803 |
| Popis: | In recent years, the incidence of lung cancer has been increasing, and lung cancer has become the leading cause of cancer-related death. Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancers. Platinum-containing chemotherapy is the first-line treatment for advanced patients. For patients with epidermal growth factor receptor ( EGFR ) mutation, EGFR-tyrosine kinase inhibitor (EGFR-TKI) is the best treatment choice. In studies, these patients have initially shown excellent response to EGFR-TKI treatment. However, the median progression-free survival (PFS) of NSCLC patients treated with EGFR-TKI is only 10–12 months, so the problem of drug resistance in treatment needs to be urgently solved. Clinical studies have shown that metformin and EGFR-TKI have synergistic effects in the treatment of NSCLC patients. Additionally, patients who are diagnosed with type 2 diabetes mellitus, with EGFR mutation have shown synergistic effects. This combination therapy can lead to longer PFS and overall survival (OS). This article reviews the synergistic effect of metformin and EGFR-TKI in the treatment of NSCLC. |
| Databáze: | OpenAIRE |
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