Vitamin B12 deficiency in African American and white octogenarians and centenarians in Georgia
| Autor: | M A, Johnson, D B, Hausman, A, Davey, L W, Poon, R H, Allen, S P, Stabler, John L, Woodard |
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| Rok vydání: | 2010 |
| Předmět: |
Gerontology
Male Aging Erythrocytes Georgia Atrophic gastritis Animal food Methylmalonic acid Ethnic group Medicine (miscellaneous) White People Article chemistry.chemical_compound Folic Acid Sex Factors medicine Humans Vitamin B12 Cyanocobalamin Homocysteine Aged 80 and over Nutrition and Dietetics business.industry Age Factors Vitamin B 12 Deficiency medicine.disease Black or African American Malnutrition B vitamins Vitamin B 12 chemistry Female Geriatrics and Gerontology business |
| Zdroj: | The journal of nutrition, healthaging. 14(5) |
| ISSN: | 1760-4788 |
| Popis: | Test the hypotheses that vitamin B12 deficiency would be prevalent in octogenarians and centenarians and associated with age, gender, race/ethnicity, living arrangements (community or skilled nursing facility), animal food intake, B-vitamin supplement use, atrophic gastritis, folate status, and hematological indicators.Population-based multi-ethnic sample of adults aged 80 to 89 and 98 and above.Northern Georgia in the United States.Men and women aged 80 to 89 (octogenarians, n = 80) and 98 and older (centenarians, n = 231).Wilcoxon signed-rank tests, Fisher's exact tests, and logistic regression analysis was used to examine the associations of vitamin B12 status with the variables of interest.After excluding participants receiving vitamin B12 injections (n = 17), the prevalence of vitamin B12 deficiency was higher in centenarians than in octogenarians (35.3% vs. 22.8%, p0.05, defined as plasma vitamin B12258 pmol/L and serum methylmalonic acid271 nmol/L and methylmalonic acidserum 2-methylcitrate) and in both age groups was correlated with significantly higher homocysteine (p0.05) and lower plasma and red cell folate (p0.01), but was not related to hemoglobin, anemia, mean cell volume, or macrocytosis. In logistic regression analysis, the probability of being vitamin B12-deficient was significantly increased by being a centenarian vs. octogenarian (p0.03), by being white vs. African American (p0.02), by increasing severity of atrophic gastritis (p0.001), and by not taking oral B-vitamin supplements (p0.01), but was not related to gender, living arrangements, or animal food intake.Centenarians and octogenarians are at high risk for vitamin B12 deficiency for many of the same reasons identified in other older adult populations. Given the numerous potential adverse consequences of poor vitamin B12 status, efforts are needed to ensure vitamin B12 adequacy in these older adults. |
| Databáze: | OpenAIRE |
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