Mild Electrophilic Halogenation of Chloropyridines Using CCl4 or C2Cl6 under Basic Phase Transfer Conditions

Autor:	Mubeen Baidossi, Nida Qafisheh, Yoel Sasson, Ashutosh V. Joshi, Elsa Chachashvili
Rok vydání:	2004
Předmět:	chemistry.chemical_compound chemistry Phase (matter) Organic Chemistry Drug Discovery Electrophile Carbon tetrachloride Electrophilic halogenation Halogenation Organic chemistry General Medicine Biochemistry Hexachloroethane
Zdroj:	ChemInform. 35
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200440141
Popis:	Effective chlorination of 2,3,5,6-tetrachloropyridine to pentachloropyridine was realized under mild phase transfer conditions with carbon tetrachloride and 50% NaOH or solid K 3 PO 4 . Mechanistic study of this reaction indicated the possibility of an aromatic carbanionic intermediate. Hexachloroethane was established as a more selective electrophilic chlorination agent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae9dcb3d3537f3152d10f69b9f6deb3 https://doi.org/10.1002/chin.200440141 Zobrazit plný text záznamu Plný text