Phenolic compounds from Sidastrum micranthum (A. St.-Hil.) fryxell and evaluation of acacetin and 7,4'-Di-O-methylisoscutellarein as motulator of bacterial drug resistence
| Autor: | Delby Fernandes de Medeiros, S. Maciel, Maria de Fátima, Maria de Fátima Agra, Rafael R. A. Ramirez, José P. Siqueira-Júnior, Vanderlei de Souza, Roosevelt A. Gomes |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
modulation of drug resistance
Acacetin Traditional medicine Tetracycline medicine.drug_class Antibiotics Sidastrum micranthum General Chemistry Biology Microbiology lcsh:Chemistry chemistry.chemical_compound lcsh:QD1-999 chemistry Genkwanin medicine Quercetin Antibacterial activity Ethidium bromide Malvaceae Norfloxacin medicine.drug |
| Zdroj: | Química Nova, Volume: 34, Issue: 8, Pages: 1385-1388, Published: 2011 Química Nova, Vol 34, Iss 8, Pp 1385-1388 (2011) Química Nova v.34 n.8 2011 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| ISSN: | 0100-4042 |
| DOI: | 10.1590/s0100-40422011000800016 |
| Popis: | From the aerial parts of Sidastrum micranthum (A. St.-Hil.) Fryxell (Malvaceae) were isolated m-methoxy-p-hydroxy-benzaldehyde, o-hydroxy-benzoic acid, acacetin, quercetin, 7,4′-Di-O-methylisoscutellarein, genkwanin and tiliroside. These compounds were identified by data analyses of spectroscopic methods. Although acacetin and 7,4′-Di-O-methylisoscutellarein did not display relevant antibacterial activity (MIC = 256 µg/mL), they modulated the activity of antibiotics, i.e. in combination with antibiotics at 64 µg/mL (¼ MIC), a two-fold reduction in the MIC was observed for norfloxacin and ethidium bromide; regarding tetracycline and erythromycin a two-fold reduction in the MIC was observed only with 7,4′-Di-O-methylisoscutellarein. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|