Age-based disparity in outcomes of intestinal transplants in pediatric patients
| Autor: | C S, Desai, F B, Maegawa, A C, Gruessner, R W, Gruessner, R W, Gruesner, K M, Khan |
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| Rok vydání: | 2012 |
| Předmět: |
United Network for Organ Sharing
Graft Rejection Male Pediatrics medicine.medical_specialty Tissue and Organ Procurement Adolescent Age groups Intestinal failure Immunology and Allergy Medicine Humans Pharmacology (medical) In patient Child Retrospective Studies Transplantation Intestinal transplants business.industry Incidence Age Factors Infant Organ Transplantation Intestines Survival Rate Viscera Treatment Outcome Child Preschool Female business |
| Zdroj: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 12 |
| ISSN: | 1600-6143 |
| Popis: | Outcomes of intestinal transplants (ITx; n = 977) for pediatric patients are examined using the United Network for Organ Sharing data from 1987 to 2009. Recipients were divided into four age groups: (1)2 years of age (n = 569), (2) 2-6 years (n = 219), (3) 6-12 years (n = 121) and (4) 12-18 years (n = 68). Of 977 ITx, 287 (29.4%) were isolated ITx and 690 (70.6%) were liver and ITx (L-ITx). Patient survival for isolated ITx at 1, 3 and 5 years, 85.3%, 71.3% and 65.0%, respectively, was significantly better than L-ITx, 68.4%, 57.0% and 51.4%, respectively, (p = 0.0001); this was true for all age groups, except for patients2 years of age. The difference in graft survival between isolated ITx and L-ITx was significant at 1 and 3 years (Wilcoxon test, p = 0.0012). After attrition analysis of graft survival of patients who survived past first year, 3 and 5 years, graft survival for L-ITx patient was significantly better than those for isolated ITx. Isolated ITx should be considered early before the onset of liver disease in children2 with intestinal failure but is not advantageous in patients2 years. |
| Databáze: | OpenAIRE |
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