Grey matter abnormalities are associated only with severe cognitive decline in early stages of Parkinson's disease

Autor: Anja J.H. Moonen, Luc Defebvre, Paul A. M. Hofman, Amée F. Wolters, Christine Delmaire, Kathy Dujardin, Frank C.G. van Bussel, Renaud Lopes, Albert F.G. Leentjens, Annelien Duits
Přispěvatelé: Neurochirurgie, MUMC+: MA AIOS Neurologie (9), RS: MHeNs - R3 - Neuroscience, MUMC+: MA Niet Med Staf Psychologie (9), Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Med Staf Spec Psychiatrie (9), Beeldvorming, MUMC+: DA BV Medisch Specialisten Radiologie (9)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
medicine.medical_specialty
Parkinson's disease
Cognitive Neuroscience
DIAGNOSTIC-CRITERIA
Motor Disorders
Experimental and Cognitive Psychology
Audiology
Grey matter
Neuropsychological Tests
SURFACE-BASED ANALYSIS
050105 experimental psychology
VALIDATION
White matter
03 medical and health sciences
0302 clinical medicine
Cognition
VISUAL HALLUCINATIONS
medicine
Dementia
Humans
0501 psychology and cognitive sciences
Cognitive Dysfunction
Disabled Persons
Neuropsychological assessment
Cognitive decline
Gray Matter
RATING-SCALE
medicine.diagnostic_test
DEMENTIA
05 social sciences
Neuropsychology
Parkinson Disease
LEWY BODY
IMPAIRMENT
medicine.disease
Magnetic Resonance Imaging
Grey matter changes
ALZHEIMERS-DISEASE
Neuropsychology and Physiological Psychology
medicine.anatomical_structure
Cross-Sectional Studies
Psychology
CORTICAL THICKNESS
030217 neurology & neurosurgery
Zdroj: Cortex, 123, 1-11. Elsevier Masson
ISSN: 0010-9452
Popis: Cognitive impairment is common in Parkinson's disease (PD), yet with large heterogeneity in the range and course of deficits. In a cross-sectional study, 124 PD patients underwent extensive clinical and neuropsychological assessment as well as a 3T MRI scan of the brain. Our aim was to identify differences in grey matter volume and thickness, as well as cortical folding, across different cognitive profiles as defined through a data-driven exploratory cluster analysis of neuropsychological data. The identified cognitive groups ranged from cognitively intact patients to patients with severe deficits in all cognitive domains, whilst showing comparable levels of motor disability and disease duration. Each group was compared to the cognitively intact PD group using voxel- and vertex-based morphometry. Results revealed widespread age-related grey matter abnormalities associated with progressive worsening of cognitive functions in mild PD. When adjusted for age, significant differences were only seen between cognitively intact and severely affected PD patients and these were restricted to the right posterior cingulate and the right precuneus. Reduced cortical thickness was seen in the right inferior temporal gyrus and reduced folding in the right temporal region. As these differences were not associated with age, we assume that they are associated with underlying pathology of the cognitive decline. Given the limited involvement of grey matter differences, and the absence of differences in vascular changes across the groups, we hypothesize a more important role for white matter tract changes in cognitive decline in PD. (C) 2019 Elsevier Ltd. All rights reserved.
Databáze: OpenAIRE
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