HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation
| Autor: | Ravindra K. Gupta, Jonathan Lambert, John Frater, Hoi Ping Mok, Dimitra Peppa, Simon Edwards, Ian H Gabriel, Andrew J. Innes, Maria Salgado, Christopher Monit, Paul Grant, Eleni Nastouli, Helen Lee, Luke Muir, M Pace, Monique Nijhuis, Annemarie M. J. Wensing, Andrew M. L. Lever, Javier Martinez-Picado, Laura Waters, Fanny Salasc, Laura E. McCoy, Sultan Abdul-Jawad, Eduardo Olavarria |
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| Přispěvatelé: | Gupta, Ravindra [0000-0001-9751-1808], Mok, Hoi Ping [0000-0003-1402-7194], Salasc, Fanny [0000-0002-6574-1358], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
CD4-Positive T-Lymphocytes
0301 basic medicine Receptors CXCR4 Receptors CCR5 General Science & Technology Cytomegalovirus HIV Infections HIV Antibodies gag Gene Products Human Immunodeficiency Virus Article Virus 03 medical and health sciences 0302 clinical medicine MD Multidisciplinary Humans Transplantation Homologous Medicine Cytotoxic T cell Multidisciplinary biology business.industry Hematopoietic Stem Cell Transplantation virus diseases Total body irradiation medicine.disease Hodgkin Disease Lymphoma Transplantation Haematopoiesis 030104 developmental biology 030220 oncology & carcinogenesis Immunology HIV-1 biology.protein Antibody Stem cell business |
| Zdroj: | Nature |
| DOI: | 10.1038/s41586-019-1027-4 |
| Popis: | HIV-1 cure remains elusive with only one reported case a decade ago. Termed the “Berlin Patient”, the individual underwent 2 allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) procedures using a donor with a homozygous mutation in the HIV coreceptor CCR5 (CCR5Δ32/Δ32) to treat his acute myeloid leukemia. Total body irradiation was given with each HSCT. Critically, it is unclear which treatment or patient parameters contributed to this only documented case of long term HIV remission. Here we show that HIV-1 remission may be possible with a less aggressive and toxic approach. An HIV-1-infected adult underwent allo-HSCT for Hodgkin’s Lymphoma using cells from a CCR5Δ32/Δ32 donor. He experienced mild gut graft versus host disease. Antiretroviral therapy was interrupted 16 months after transplantation. HIV-1 remission has been maintained through a further 18 months. Plasma HIV-1 RNA has been undetectable at NIHR AmFAR |
| Databáze: | OpenAIRE |
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