Structure-Activity Relationships of Phenyl- and Benzoylpyrroles
| Autor: | Heinz Pudleiner, Gerhard Hamprecht, Michael Kellner, Ulf Hanefeld, Heidrun Anke, Hans-Peter Kraemer, Hartmut Laatsch, Bernd Renneberg |
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| Rok vydání: | 1995 |
| Předmět: |
Stereochemistry
Melanoma Experimental Substituent Antineoplastic Agents 010402 general chemistry 01 natural sciences Chemical synthesis Lethal Dose 50 Mice Structure-Activity Relationship chemistry.chemical_compound Anti-Infective Agents Nucleophile Drug Discovery Animals Pyrroles Leukemia L1210 Antibacterial agent Pyrrole 010405 organic chemistry Chemistry Hydrogen bond organic chemicals Hydrogen Bonding General Chemistry General Medicine Plants 0104 chemical sciences Mice Inbred C57BL Mice Inbred DBA Covalent bond Pentabromopseudilin Female |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 43:537-546 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.43.537 |
| Popis: | Antitumor, antimicrobial, and phytotoxic activities of the marine antibiotic pentabromopseudilin (1a) and related phenyl-, benzyl- and benzoyl pyrroles were compared. All activities depended strongly on the substituent pattern, with the natural compound 1a being the most active one. As judged from model reactions, a covalent bond of nucleophiles to the pyrrole system may be involved in the inhibition of macromolecular syntheses. |
| Databáze: | OpenAIRE |
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