Metabolic effects of ethacrynic acid in the aged
| Autor: | Gilbert Rosenberg, Joseph Wener |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Potassium Sodium chemistry.chemical_element Blood Urea Nitrogen Diabetes Complications Maintenance therapy Chlorides Internal medicine Diabetes mellitus Medicine Humans Blood urea nitrogen Aged Heart Failure business.industry Glucose Tolerance Test medicine.disease Long-Term Care Uric Acid Endocrinology Ethacrynic Acid Metabolism chemistry Metabolic effects Heart failure Female Geriatrics and Gerontology Diuretic business |
| Zdroj: | Journal of the American Geriatrics Society. 18(9) |
| ISSN: | 0002-8614 |
| Popis: | Ethacrynic acid was given to 41 aged men and women who had previously been treated with thiazides for congestive heart failure. Twenty-three of these patients had diabetes. After ten weeks of maintenance therapy with ethacrynic acid, there were no statistically significant changes in the levels of blood urea nitrogen, serum uric acid, chloride, sodium and potassium. Glucose tolerance was not adversely affected; rather, glucose tolerance improved (P < .05) in the 20 diabetic patients tested. Of the 41 patients, 7 had gastrointestinal symptoms of mild to moderate severity for one to three days, but when ethacrynic acid was started again these symptoms did not recur. Ethacrynic acid, as used in the present study, would appear to be an effective, relatively safe diuretic, particularly well suited for long-term use in patients with diabetes mellitus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text