Ichthyosis fetalis in Polled Hereford and Shorthorn calves
| Autor: | Pietro Parma, Jillian Kelly, Brendon A. O’Rourke, Maria Longeri, Naomi S. Porter, Patrick Shearer, Zoe B. Spiers |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Hyperkeratosis Physiology Cattle Diseases 03 medical and health sciences medicine Animals Genetic Predisposition to Disease ABCA12 Autosome integumentary system General Veterinary biology Ichthyosis 0402 animal and dairy science 04 agricultural and veterinary sciences medicine.disease 040201 dairy & animal science 030104 developmental biology Shorthorn Hereditary Diseases Mutation biology.protein Histopathology Allelic heterogeneity Cattle |
| Zdroj: | Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 29(6) |
| ISSN: | 1943-4936 |
| Popis: | Inherited forms of ichthyosis, or generalized scaling of the skin, have been reported in many animal species, including cattle, and are characterized by an autosomal recessive mode of inheritance. We investigated 2 calves affected with ichthyosis fetalis, a Polled Hereford and a Shorthorn. Both cases had hard white plaques on the skin consistent with excessive keratinization. This was confirmed by histopathology, which showed severe diffuse epidermal and follicular orthokeratotic hyperkeratosis. The known mutation (H1935R) in gene ABCA12, responsible for ichthyosis fetalis in Chianina cattle, was shown to be absent in both affected calves and their obligate heterozygous parents. These molecular findings indicate that allelic heterogeneity exists for this condition in cattle. |
| Databáze: | OpenAIRE |
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