Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegration
| Autor: | Elcio Marcantonio, Rosemary Adriana Chierici Marcantonio, Mauricio Andrés Tinajero Aroni, Felipe Eduardo Pinotti, Guilherme José Pimentel Lopes de Oliveira |
|---|---|
| Přispěvatelé: | Universidade Federal de Uberlândia (UFU), Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Materials science Bone Regeneration Low-level laser therapy medicine.medical_treatment Bone Morphogenetic Protein 2 Dermatology Bone healing Bone morphogenetic protein 2 Osseointegration 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Laser therapy medicine Image Processing Computer-Assisted Animals Tibia Low-Level Light Therapy Bone regeneration Low level laser therapy Bone substitutes 030206 dentistry Biomechanical Phenomena Rats Implant placement Preclinical study Bone Substitutes Surgery Cattle Hydroxyapatites Biomedical engineering |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2020-12-12T01:56:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) The aim of this study was to evaluate the osseointegration of implants placed in areas grafted with different osteoconductive bone substitutes irradiated with infrared low-level laser therapy (LLLT). Fifty-six rats were randomly allocated into 4 groups: DBB, bone defects filled with deproteinized bovine bone graft (DBB); HA/TCP, bone defects filled with biphasic ceramic made of hydroxyapatite and β-tricalcium phosphate (HA/TCP); DBB-L, bone defects filled with DBB and treated by LLLT; HA/TCP-L, bone defects filled with HA/TCP and treated by LLLT. Bone defects were performed in the tibia of each animal and filled with the different biomaterials. The grafted areas were treated with LLLT (λ 808 nm, 100 mW, ϕ ∼ 0.60 mm) in 7 sessions with 48 h between the irradiations. After the 60-day period, the implants were placed, and the animals were euthanized after 15 and 45 days. The osseointegration and bone repair in the grafted area were evaluated by biomechanical, microtomographic and histometric analyses, and the expression of some bone biomarkers was evaluated by immunohistochemistry analysis. LLLT induced higher degree of osseointegration, which was associated with the greater expression of BMP2 and OCN. LLLT performed in areas grafted with osteoconductive bone substitutes prior to implant placement improves osseointegration. Department of Periodontology Dental School Universidade Federal de Uberlândia (UFU), Pará Av, 1720 Department of Diagnosis and Surgery School of Dentistry Campus of Araraquara São Paulo State University (UNESP), Humaitá St. 1680 Department of Diagnosis and Surgery School of Dentistry Campus of Araraquara São Paulo State University (UNESP), Humaitá St. 1680 FAPESP: 2013/24318-0 CNPq: 459984/2014-4 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|