Nucleotide sequence of the genes encoding the matrix protein of two wild-type measles virus strains
| Autor: | K. Baczko, I. Pardowitz, Bertus K. Rima, U. Brinckmann, V. ter Meulen |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Paramyxoviridae
Molecular Sequence Data Virus Measles virus Viral Matrix Proteins Morbillivirus Virology Coding region Animals Humans Cloning Molecular Gene Vero Cells Genetics biology Nucleic acid sequence biology.organism_classification Biological Evolution Maximum parsimony DNA Viral Encephalitis RNA Viral Subacute Sclerosing Panencephalitis Measles |
| Zdroj: | The Journal of general virology. 72 |
| ISSN: | 0022-1317 |
| Popis: | The nucleotide sequences of the matrix protein (M) genes of two wild-type measles virus (MV) isolates (JM and CM) have been determined and shown to differ in 56 positions; 31 of these differences are located in the non-coding region and 25 in the coding region of the gene. Most (80%) of the mutations in the coding region are changes to the third base of a codon. A maximum parsimony analysis of the available M gene nucleotide sequences allowed the construction of a tree with at least three lineages or subtypes. One wild-type strain (JM) was very similar to a subacute sclerosing panencephalitis virus strain (case B); the second wild-type strain, CM, showed nucleotide sequence similarity with MV from a case of measles inclusion body encephalitis. Both wild-type virus sequences are distinct from those so far determined for vaccine strains. |
| Databáze: | OpenAIRE |
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