Reactivity to human papillomavirus type 16 L1 virus-like particles in sera from patients with genital cancer and patients with carcinomas at five different extragenital sites
| Autor: | Joakim Dillner, G. J. J. Van Doornum, Johannes M.G. Bonfrer, B. G. Taal, Johanna C.G.M. Buning-Kager, Simon Horenblas, Catharina M. Korse |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Esophageal Neoplasms cervical cancer Genital Neoplasms Female Papillomavirus E7 Proteins Antibodies Viral Viral Proteins Seroepidemiologic Studies Penile Carcinoma medicine Carcinoma Humans Papillomaviridae Laryngeal Neoplasms Aged Cervical cancer biology business.industry Molecular and Cellular Pathology Virion virus diseases Cancer Oncogene Proteins Viral oropharyngeal carcinoma Middle Aged medicine.disease biology.organism_classification vaginal and vulvar cancer Tongue Neoplasms Oropharyngeal Neoplasms oesophageal carcinoma Oncology Oropharyngeal Carcinoma penile carcinoma HPV 16 serology Genital Neoplasms Male biology.protein Capsid Proteins Female Viral disease Antibody business |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | A retrospective seroepidemiologic study was performed to examine the association between human papillomaviruses (HPV) 16 infection and carcinomas of the oropharynx, the oesophagus, penis and vagina. Sera were selected from the serum bank from the Antoni van Leeuwenhoek Hospital (Netherlands Cancer Institute) and the Slotervaart Hospital in Amsterdam, the Netherlands. Presence of HPV 16 specific antibody was assessed using HPV 16 L1 capsids. Sera positive for HPV 16 capsid antibody were further tested for antibody against HPV 16 E7 peptides. Prevalence of antibody against HPV 16 L1 capsids among both the negative control group without cancer and the negative control group with gastric cancer was 18%, while seroprevalence among the control group of patients with HPV-associated cervical squamous cell carcinoma was 47% (P |
| Databáze: | OpenAIRE |
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