Bioactive Components of Polyphenol-Rich and Non-Polyphenol-Rich Cranberry Fruit Extracts and Their Chemopreventive Effects on Colitis-Associated Colon Cancer
| Autor: | Anuradha Tata, Catherine C. Neto, Mingyue Song, Hang Xiao, Xian Wu, Liang Xue |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Male Colorectal cancer Pharmacology medicine.disease_cause Protective Agents 01 natural sciences Proinflammatory cytokine Terpene Mice Gene expression medicine Animals Humans Colitis Chemistry Plant Extracts 010401 analytical chemistry Polyphenols General Chemistry medicine.disease 0104 chemical sciences Vaccinium macrocarpon Proanthocyanidin Polyphenol Fruit Colitis-Associated Neoplasms General Agricultural and Biological Sciences Carcinogenesis 010606 plant biology & botany |
| Zdroj: | Journal of agricultural and food chemistry. 68(25) |
| ISSN: | 1520-5118 |
| Popis: | Cranberries contain various constituents relevant to human health. Our previous study demonstrated the chemopreventive effects of whole cranberry against colon cancer in mice. In order to determine the role of different cranberry secondary metabolites in inhibiting colon cancer, cranberry ethyl acetate extract (EAE) and polyphenol extract (PPE) were obtained. The free-radical scavenging activities and chemical composition of the cranberry extracts were determined. EAE consisted of triterpenes and sterols and a trace amount of proanthocyanidins. PPE mainly contained polyphenol with a trace amount of triterpenes. The chemopreventive effects of orally administered EAE and PPE on colitis-associated colon carcinogenesis were determined in mice. Dietary EAE and PPE significantly suppressed tumor metrics without noticeable adverse effects. Gene expression levels of key proinflammatory cytokines were also attenuated by EAE and PPE in the mouse colon. In conclusion, the novel cranberry extracts may offer an efficacious and safe means to prevent colonic tumorigenesis in humans. |
| Databáze: | OpenAIRE |
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