Identification and characterization of a new member of the TNF family that induces apoptosis
| Autor: | Pamela J. Smolak, Ken Schooley, Jillian Nicholl, Grant R. Sutherland, Terri Davis Smith, Craig A. Smith, Chang-Pin Huang, Steven R. Wiley, Wenie S. Din, Raymond G. Goodwin, Charles Rauch |
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| Jazyk: | angličtina |
| Předmět: |
DNA
Complementary Cell Molecular Sequence Data Immunology Decoy Receptor 1 Apoptosis Biology Cell Line TNF-Related Apoptosis-Inducing Ligand Mice medicine Animals Humans Immunology and Allergy Amino Acid Sequence Decoy receptors Cloning Molecular Gene Membrane Glycoproteins Base Sequence Tumor Necrosis Factor-alpha Chromosome Mapping Molecular biology Cell biology medicine.anatomical_structure Infectious Diseases Membrane protein Tumor necrosis factor alpha Chromosomes Human Pair 3 Apoptosis Regulatory Proteins Sequence Alignment Tumor Necrosis Factor Decoy Receptors |
| Zdroj: | Immunity. (6):673-682 |
| ISSN: | 1074-7613 |
| DOI: | 10.1016/1074-7613(95)90057-8 |
| Popis: | A novel tumor necrosis factor (TNF) family member has been cloned and characterized. This protein, designated TNF-related apoptosis-Inducing ligand (TRAIL), consists of 281 and 291 as in the human and murine forms, respectively, which share 65% as identity. TRAIL is a type II membrane protein, whose C-terminal extracellular domain shows clear homology to other TNF family members. TRAIL transcripts are detected in a variety of human tissues, most predominantly in spleen, lung, and prostate. The TRAIL gene is located on chromosome 3 at position 3q26, which is not close to any other known TNF ligand family members. Both full-length cell surface expressed TRAIL and picomolar concentrations of soluble TRAIL rapidly induce apoptosis in a wide variety of transformed cell lines of diverse origin. |
| Databáze: | OpenAIRE |
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