Randomized, Open-Label, Comparative Study of Piperacillin-Tazobactam Administered by Continuous Infusion versus Intermittent Infusion for Treatment of Hospitalized Patients with Complicated Intra-Abdominal Infection
| Autor: | Kamal M.F. Itani, Debra Mansfield, Joseph L. Kuti, Adrian Dana, David P. Nicolau, David W. Mercer, William Lau |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Tazobactam medicine.medical_specialty Randomization Adolescent Penicillanic Acid Penicillins Clinical Therapeutics Double-Blind Method Abdomen medicine Humans Pharmacology (medical) Enzyme Inhibitors Infusions Intravenous Adverse effect APACHE Aged Antibacterial agent Pharmacology business.industry Bacterial Infections Middle Aged Surgery Hospitalization Drug Combinations Infectious Diseases medicine.anatomical_structure Piperacillin/tazobactam Female business Complication Piperacillin medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 50:3556-3561 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.00329-06 |
| Popis: | The purpose of this randomized, multicenter, open-label study was to compare the continuous infusion of piperacillin-tazobactam with the standard intermittent infusion in 262 hospitalized patients with complicated intra-abdominal infections. Within 1 day of surgical intervention, eligible patients were randomized (1:1) to piperacillin-tazobactam 12 g/1.5 g administered continuously over 24 h or 3 g/0.375 g administered over 30 min intermittently every 6 h for 4 to 14 days. The demographics of the patients in the groups were similar, with a median APACHE II score of 7 and a median length of hospitalization of 7 days. Among 167 clinically evaluable patients, 86.4% and 88.4% of the patients treated with the continuous infusion and the intermittent infusion, respectively, were clinically cured or improved at the test-of-cure visit ( P = 0.817). Bacteriological success was observed in 83.9% and 87.9% of patients ( P = 0.597) in the two groups, respectively, and no differences in bacteriological response by pathogen were noted. Defervesence and white blood cell count normalization occurred in the majority of patients within 3 days and were similar between patients receiving the continuous infusion and those receiving the intermittent infusion. Drug-related adverse events were generally mild and were reported in similar numbers of patients in each arm of the trial. The results of this study support continuous infusion as a safe and reasonable alternate mode of administration of piperacillin-tazobactam for the treatment of complicated intra-abdominal infection. |
| Databáze: | OpenAIRE |
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