Sustained Activation of PV+ Interneurons in Core Auditory Cortex Enables Robust Divisive Gain Control for Complex and Naturalistic Stimuli
| Autor: | K. Jannis Hildebrandt, Jennifer F. Linden, Pedro J. Gonçalves, Maneesh Sahani, Tina Gothner |
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| Rok vydání: | 2020 |
| Předmět: |
Computer science
Cognitive Neuroscience Sensory system Optogenetics Stimulus (physiology) Core auditory cortex Inhibitory postsynaptic potential Auditory cortex 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Interneurons Animals Automatic gain control 030304 developmental biology Auditory Cortex Neurons 0303 health sciences biology musculoskeletal neural and ocular physiology Parvalbumins nervous system biology.protein Cortical inhibition Somatostatin Neuroscience 030217 neurology & neurosurgery Parvalbumin |
| Zdroj: | Cerebral Cortex |
| ISSN: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhaa347 |
| Popis: | Sensory cortices must flexibly adapt their operations to internal states and external requirements. Sustained modulation of activity levels in different inhibitory interneuron populations may provide network-level mechanisms for adjustment of sensory cortical processing on behaviorally relevant timescales. However, understanding of the computational roles of inhibitory interneuron modulation has mostly been restricted to effects at short timescales, through the use of phasic optogenetic activation and transient stimuli. Here, we investigated how modulation of inhibitory interneurons affects cortical computation on longer timescales, by using sustained, network-wide optogenetic activation of parvalbumin-positive interneurons (the largest class of cortical inhibitory interneurons) to study modulation of auditory cortical responses to prolonged and naturalistic as well as transient stimuli. We found highly conserved spectral and temporal tuning in auditory cortical neurons, despite a profound reduction in overall network activity. This reduction was predominantly divisive, and consistent across simple, complex, and naturalistic stimuli. A recurrent network model with power-law input–output functions replicated our results. We conclude that modulation of parvalbumin-positive interneurons on timescales typical of sustained neuromodulation may provide a means for robust divisive gain control conserving stimulus representations. |
| Databáze: | OpenAIRE |
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