Inflammatory Hepatocellular Adenoma with Elevated Serum Protein Induced by Vitamin K Absence/Antagonist-II in Adult Males
| Autor: | Mayumi Tai, Yudai Koya, Yutaka Ejiri, Masaru Harada, Michihiko Shibata, Nobuo Matsuhashi, Masatsugu Miyazawa, Tomohiro Suzuki, Tsutomu Kumabe, Osamu Ichii, Osamu Nakashima |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male malignant transformation medicine.medical_specialty Liver tumor Case Report 030204 cardiovascular system & hematology Vitamin k Gastroenterology Adenoma Liver Cell Malignant transformation 03 medical and health sciences 0302 clinical medicine Internal medicine Biopsy Biomarkers Tumor Internal Medicine Humans Medicine inflammatory hepatocellular adenoma Protein Precursors medicine.diagnostic_test business.industry Liver Neoplasms Antagonist General Medicine Hepatocellular adenoma beta-catenin activation protein induced by vitamin K absence/antagonist-II medicine.disease Inflammatory Hepatocellular Adenoma Immunohistochemistry Prothrombin 030211 gastroenterology & hepatology business Biomarkers |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.1958-18 |
| Popis: | Two men (24 and 34 years of age) with a single hypervascular liver tumor were admitted to our hospital. The tumors were diagnosed as hepatocellular adenoma (HCA) by an ultrasound-guided biopsy and classified as inflammatory type by immunohistochemical staining. Considering the risk of malignant transformation, they underwent surgical resection. Although the serum levels of protein induced by vitamin K absence/antagonist-II (PIVKA-II) were slightly elevated, they normalized after the resection. The diagnosis of HCA including malignant transformation is often difficult by image findings alone. Careful immunohistochemical examinations are very useful for the diagnosis and classification of subgroups, including malignant transformation. In addition, we proved that HCA without malignant transformation expresses PIVKA-II. |
| Databáze: | OpenAIRE |
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