Connexin-Mediated Signaling at the Immunological Synapse
| Autor: | Flavio Salazar-Onfray, Mariela Navarrete, Peter J. Gebicke-Haerter, Andrés Tittarelli, María Alejandra Gleisner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
cytotoxic immunological synapse
connexin-43 Immunological Synapses T cell T-Lymphocytes Connexin Review Catalysis Immunological synapse Inorganic Chemistry gap junction lcsh:Chemistry chemistry.chemical_compound Immune system medicine Cytotoxic T cell Animals Humans Cyclic adenosine monophosphate Protein Interaction Maps Physical and Theoretical Chemistry Antigen-presenting cell Molecular Biology lcsh:QH301-705.5 Spectroscopy Chemistry Organic Chemistry immunological synapse General Medicine Dendritic Cells Computer Science Applications Cell biology medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 Connexin 43 Second messenger system signaling Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 3736, p 3736 (2020) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | The immunological synapse (IS) is an intercellular communication platform, organized at the contact site of two adjacent cells, where at least one is an immune cell. Functional IS formation is fundamental for the modulation of the most relevant immune system activities, such as T cell activation by antigen presenting cells and T cell/natural killer (NK) cell-mediated target cell (infected or cancer) killing. Extensive evidence suggests that connexins, in particular connexin-43 (Cx43) hemichannels and/or gap junctions, regulate signaling events in different types of IS. Although the underlying mechanisms are not fully understood, the current evidence suggests that Cx43 channels could act as facilitators for calcium ions, cyclic adenosine monophosphate, and/or adenosine triphosphate uptake and/or release at the interface of interacting cells. These second messengers have relevant roles in the IS signaling during dendritic cell-mediated T and NK cell activation, regulatory T cell-mediated immune suppression, and cytotoxic T lymphocyte or NK cell-mediated target tumor cell killing. Additionally, as the cytoplasmic C-terminus domain of Cx43 interacts with a plethora of proteins, Cx43 may act as scaffolds for integration of various regulatory proteins at the IS, as suggested by the high number of Cx43-interacting proteins that translocate at these cell-cell interface domains. In this review, we provide an updated overview and analysis on the role and possible underlying mechanisms of Cx43 in IS signaling. |
| Databáze: | OpenAIRE |
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